Remimazolam vs Propofol Outcomes in Elderly Thoracic Surgery Patients

A retrospective cohort study of 342 patients aged 65 years and older undergoing elective VATS lobectomy between 2020 and 2023. The research, authored by Jingjing Zhang, compares cognitive, pulmonary, and hemodynamic outcomes between remimazolam- and propofol-based anesthesia using propensity score matching.

Use Cases

• Compare postoperative cognitive recovery based on Mini-Mental State Examination (MMSE) scores at multiple time points.
• Analyze pulmonary function outcomes based on FEV₁% predicted and lung ultrasound scores.
• Investigate hemodynamic stability based on time-weighted mean arterial pressure and cerebral oxygen saturation.
• Model the association between anesthetic choice and postoperative morbidity rates for delirium and pulmonary complications.

Strengths

• Employs rigorous propensity score matching on 13 pre-specified covariates, resulting in 122 well-balanced patient pairs.
• Reports specific, statistically significant outcome differences, such as a 3.6-point higher mean MMSE score at 24 hours for the remimazolam group.
• Uses a standardized, driving pressure-guided individualized PEEP protocol, suggesting a controlled clinical environment.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Data may reflect temporal bias inherent to the 2020-2023 study period.

Provenance

Source

figshare

Collection Method

Retrospective cohort study using hospital records.

Time Range

2020-2023

Freshness

Last updated 2026-06-03 05:42:59; freshness should be verified.