Recombinant Zoster Vaccine Safety and Immunogenicity in SD Rats

Four doses of a recombinant zoster vaccine were administered to adult Sprague-Dawley rats to assess safety and immunogenicity. The study includes data from general health observations, immunotoxicity and immunogenicity assays, hematological and biochemical profiling, and histopathological evaluations. Qian Yang published the dataset on figshare in 2026 under a CC-BY-4.0 license.

Use Cases

• Benchmarking vaccine safety profiles based on the reported no-observed-adverse-effect level (NOAEL)
• Analyzing immunogenicity based on the described cellular and humoral response data
• Comparing adjuvant effects based on the changes observed in the adjuvant control group
• Supporting clinical trial applications based on the systematic toxicology program results

Strengths

• Dataset includes a comprehensive non-clinical safety assessment with multiple evaluation methods mentioned in the description
• The no-observed-adverse-effect level (NOAEL) is explicitly stated as 1.0 mL per rat

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• The dataset is very small (10.1 KB), indicating limited scope

Provenance

Source

figshare

Collection Method

Data likely originates from a laboratory study conducted to support clinical trial entry.

Freshness

Last updated 2026-05-22 05:35:49; freshness should be verified