Clinical Trial Protocol for rTMS Treatment of Fatigue in Multiple Sclerosis

A study protocol document for a randomized, double-blinded, sham-controlled clinical trial investigating repetitive transcranial magnetic stimulation (rTMS) for fatigue in multiple sclerosis. The protocol describes the methodology for a trial involving 58 patients, with primary and secondary outcomes including the Fatigue Scale for Motor and Cognitive Functions (FSMC) score and 7T magnetic resonance spectroscopy measurements. The document was authored by Sofus Nygaard and uploaded to figshare in March 2026.

Use Cases

• Analyzing clinical trial design for neuromodulation interventions based on the described randomized, double-blinded, sham-controlled methodology.
• Studying the relationship between cortical excitation-inhibition balance and fatigue based on the planned GABA and glutamate concentration measurements.
• Benchmarking outcome measures for fatigue in multiple sclerosis based on the use of the FSMC score and other assessments.
• Reviewing neuroimaging protocols for mechanistic studies based on the integration of 7T magnetic resonance spectroscopy and imaging.

Strengths

• The protocol is for a rigorously designed randomized, double-blinded, sham-controlled trial.
• Includes specific neurophysiological measurements (GABA/glutamate via 7T MRS) for mechanistic insight.
• Clearly defines a primary endpoint (FSMC score change) and secondary/exploratory outcomes.

Limitations

• The dataset is a 26.8 KB DOCX document, not the raw clinical trial data.
• Row count and column-level documentation for any potential data are absent.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare

Collection Method

Uploaded study protocol document.

Time Range

Protocol dated for a future trial (last updated 2026).

Freshness

Last updated 2026-03-18 07:38:17; freshness should be verified.

Geography

Geographic coverage of the trial is not specified.