Reserpine-Induced Fibromyalgia Model in Female Rats: Pain and Opioid Receptor Data

Table 1_Reserpine-induced fibromyalgia model in female rats is a long-lasting painful condition masked by antinociceptive endogenous opioids.docx is a research document describing a study on a fibromyalgia-like pain model in female Wistar rats. The study, authored by Cristina Juárez-Núñez and last updated in March 2026, investigates the role of endogenous opioids in masking long-term pain hypersensitivity induced by reserpine. The dataset includes results from behavioral tests and serum β-endorphin concentration measurements.

Use Cases

• Analyzing the time course of hyperalgesia and allodynia based on the described behavioral testing schedule.
• Studying the effect of opioid receptor antagonists like naloxone and naltrexone based on the reinstatement of hypersensitivity experiments.
• Investigating serum β-endorphin concentration changes in response to reserpine administration based on the ELISA results mentioned.
• Modeling the activation of spinal µ and δ opioid receptors in masking chronic pain based on the study's conclusions.

Strengths

• Data is associated with a specific, peer-reviewed research methodology described in the background and methods sections.
• The dataset has a clear license (CC-BY-4.0) permitting reuse with attribution.
• The study includes multiple time points for assessment, up to day 45 post-reserpine administration.

Limitations

• The dataset is very small (18.5 KB), suggesting it is a summary document rather than raw experimental data.
• Column-level documentation is absent; field semantics must be inferred from the textual description.
• Row count is unknown, which may limit suitability assessment for quantitative analysis.

Provenance

Source

Cristina Juárez-Núñez via figshare

Collection Method

Experimental study involving subcutaneous reserpine administration, behavioral testing, and serum ELISA in female Wistar rats.

Freshness

Last updated 2026-03-18 06:42:24; freshness should be verified.