Mycobacterium Tuberculosis Respiratory Chain Gene Mutations Linked to Drug Resistance

13,402 isolates of Mycobacterium tuberculosis were analyzed via whole-genome sequencing. The study, authored by Qiang Ji and last updated in May 2026, identified specific single nucleotide polymorphisms (SNPs) in respiratory chain genes significantly associated with multidrug-resistant (MDR) and single-drug resistant (SDR) isolates.

Use Cases

• Identifying genetic markers for drug resistance based on the described respiratory chain gene SNPs.
• Training predictive models for phylogenetic clustering of MDR isolates based on the mutation data.
• Investigating the role of the respiratory chain in tuberculosis drug resistance development based on the study's findings.

Strengths

• Data is derived from a substantial cohort of 13,402 Mycobacterium tuberculosis isolates.
• Analysis identifies specific SNPs (e.g., atpH A428G, cydA C942A) with reported statistical significance to MDR and phylogenetic clustering.
• Dataset is openly available under a CC-BY-4.0 license.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The 158.8 KB file size suggests a limited scope, likely containing summary or processed results rather than raw sequence data.

Provenance

Source

figshare, author Qiang Ji.

Collection Method

Whole-genome sequencing was performed on analyzed strains, with random forest, gradient boosting decision tree, and generalized linear mixed models used for analysis.

Time Range

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Freshness

Last updated 2026-05-20 04:38:21; freshness should be verified.

Geography

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