Retinoic Acid Effects on Porcine PRRSV Infection Transcriptomics

Figshare dataset from Jintong Guo contains transcriptomic profiling data on porcine alveolar macrophages (PAMs) treated with retinoic acid and infected with PRRSV. The data supports findings that retinoic acid inhibits viral infection and modulates inflammatory and metabolic pathways. The dataset is stored in a 48.2 KB XLS file.

Use Cases

• Analyze transcriptomic profiles from uninfected PAMs to identify immune signaling pathways upregulated by ATRA treatment.
• Compare gene expression in PRRSV-infected PAMs with and without ATRA to study reversal of hyperinflammatory responses.
• Investigate alterations in lipid homeostasis pathways from transcriptomic data of infected PAMs treated with ATRA.

Strengths

• Data originates from a peer-reviewed experimental study evaluating antiviral efficacy.
• Includes transcriptomic profiling from both cell lines (MARC-145) and primary cells (PAMs).
• Dataset is openly shared under a CC BY 4.0 license.

Limitations

• The dataset is very small at 48.2 KB, indicating limited scope or summary-level data.
• Specific row count, column names, and sample data are unavailable for detailed assessment.
• Data is derived from a controlled lab study, limiting direct applicability to field conditions.

Provenance

Source

Jintong Guo, via figshare.

Collection Method

Experimental data from in vitro studies on MARC-145 cells and primary porcine alveolar macrophages, including transcriptomic profiling.

Freshness

Last updated in March 2026.