Post-Hoc Analysis of Non-Invasive Vagus Nerve Stimulation for Chronic mTBI with PTSD

Table 1_Retrospective post-hoc subgroup analysis of adjunctive non-invasive vagus nerve stimulation in chronic mTBI with comorbid PTSD.docx is a 22.8 KB document containing a post-hoc analysis of a retrospective observational cohort study. The dataset, authored by Michael Ament and last updated on 2026-04-13, analyzes symptom changes in adults with chronic mild traumatic brain injury and comorbid PTSD treated with adjunctive non-invasive vagus nerve stimulation.

Use Cases

• Analyze treatment efficacy based on Neurobehavioral Symptom Inventory (NSI) total score changes.
• Compare symptom domain improvements (affective, cognitive, somatic, vestibular) between patient subgroups.
• Identify high-symptom-burden patient phenotypes using multivariate analysis methods described.
• Assess the proportion of patients achieving clinically meaningful improvement thresholds (e.g., ≥30% symptom reduction).

Strengths

• Includes specific quantitative results, such as a mean NSI total score reduction from 2.50 ± 0.60 to 2.03 ± 0.46.
• Reports statistically significant, FDR-corrected outcomes for multiple symptom domains.
• Provides patient-level improvement metrics, such as 40% achieving a ≥30% symptom reduction.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small at 22.8 KB, indicating limited scope.

Provenance

Source

Michael Ament via figshare.

Collection Method

Post-hoc subgroup analysis of a previously published retrospective observational cohort.

Freshness

Last updated 2026-04-13 05:44:21; freshness should be verified.