DEHP Skin Cancer Biomarkers and Molecular Docking Results

11 key molecular targets for the plasticizer DEHP in skin cancer were identified through network toxicology and molecular docking. The dataset likely contains results from topological analysis, enrichment pathways, and docking scores. Haidong Zhou published this research data on figshare in May 2026.

Use Cases

• Validate biomarker dysregulation in skin cancer based on the 11 identified core targets.
• Analyze pathway enrichment for cellular processes like proliferation and apoptosis mentioned in the description.
• Assess molecular docking stability between DEHP and targets like CTNNB1 or AKT1.

Strengths

• Identifies 11 specific molecular targets (e.g., CTNNB1, AKT1) linked to DEHP exposure.
• Integrates results from multiple validation methods, including TCGA/GTEx transcriptomic data and in vitro experiments.
• Published under a CC-BY-4.0 license, allowing for reuse and modification.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The 77.4 KB file size suggests a limited scope, likely containing summary results rather than raw experimental data.

Provenance

Source

figshare

Collection Method

Generated through integrated network toxicology, molecular docking, and experimental validation as described.

Freshness

Last updated 2026-05-21 04:19:26; freshness should be verified.