Rikkunshito Effects on IBS Mouse Model: Colonic Function, Hormones, and TRP Channels

Woo-Gyun Choi published data on May 22, 2026, investigating the effects of the herbal medicine Rikkunshito in a zymosan-induced irritable bowel syndrome mouse model. The dataset likely contains results from in vitro and in vivo experiments measuring colonic pacemaker activity, inflammation markers, gastrointestinal hormones, pain-related behaviors, and transient receptor potential channel currents. The data is shared under a CC-BY-4.0 license on figshare.

Use Cases

• Analyzing the relationship between Rikkunshito treatment and colonic pacemaker potential amplitude based on in vitro recordings from interstitial cells of Cajal.
• Modeling the effects of Rikkunshito on neuroendocrine balance based on measured levels of hormones like VIP, NPY, and 5-HT.
• Investigating the modulation of TRP channel activity (TRPV1, TRPV4, TRPA1) by Rikkunshito based on whole-cell patch-clamp recordings.
• Correlating treatment outcomes with colonic pathology, inflammation scores, and pain-related behavioral data from the mouse model.

Strengths

• Data is derived from a multi-method study combining in vitro electrophysiology, molecular biology, and in vivo behavioral assessments.
• The description provides a detailed mechanistic pathway involving ghrelin receptor–Ca2+ signaling and specific TRP channels.
• The dataset is openly shared under a permissive CC-BY-4.0 license.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small at 669.7 KB, indicating limited scope.

Provenance

Source

Woo-Gyun Choi via figshare.

Collection Method

Experimental data from a preclinical study using a zymosan-induced IBS mouse model, UPLC analysis, electrophysiological recordings, and molecular assays.

Freshness

Last updated 2026-05-22 11:18:01; freshness should be verified.