Risk Factors for Growth Pain Disorder in Children: A Systematic Review and Meta-Analysis

37 clinical studies involving 16,086 participants were analyzed to identify 17 potential risk factors for growth pain disorder in children. Ting Luo authored this systematic review, which synthesizes evidence up to October 2025. The results highlight associations with lower serum vitamin D, bone density, hypermobility, and psychosocial factors.

Use Cases

• Identify biological risk markers for growth pain disorder based on reported associations with vitamin D levels and bone density.
• Analyze behavioral and genetic correlations based on mentions of hypermobility, physical activity, and family history.
• Assess the strength of evidence for various factors based on the meta-analysis of 37 studies.
• Guide clinical diagnostic protocols based on the synthesized evidence for risk factors.
• Prioritize research areas based on the review's identification of factors with limited or no supporting evidence.

Strengths

• Aggregates findings from 37 distinct clinical studies.
• Includes data from 16,086 total participants.
• Reports specific statistical measures (SMD, OR, MD) for several risk factors.
• Provides a PROSPERO registration number (CRD420251150931) for traceability.

Limitations

• The underlying data is a 17.9 KB DOCX file, suggesting limited raw data scope.
• Column-level documentation is absent; field semantics must be inferred from the review text.
• The review notes heterogeneity and sample size limitations in the included studies, which may affect generalizability.

Provenance

Source

figshare

Collection Method

Systematic review and meta-analysis of seven electronic databases.

Time Range

Studies searched from database inception to October 2025.

Freshness

Last updated 2026-05-18 05:31:21.