Risk Factors for Vertebral Fracture After Vertebroplasty

429 patients from a single hospital were analyzed to identify predictors of adjacent vertebral fracture following percutaneous vertebroplasty. The dataset includes clinical variables such as age, bone mineral density, BMI, and bone cement leakage. Author Cheng Li published this retrospective study in 2026 using patient records from 2019 to 2024.

Use Cases

• Predict the binary outcome of adjacent vertebral fracture (AVF) using patient age and bone mineral density (BMD) T-score as primary features.
• Assess the correlation between body mass index (BMI) and fracture risk within a cohort of 143 AVF cases versus 286 controls.
• Evaluate the predictive performance of a combined model using age and BMD, which achieved an AUC of 0.706 in the original analysis.
• Investigate the role of bone cement leakage as a potential surgical risk factor for subsequent vertebral fractures.

Strengths

• Dataset contains 429 patient records with a clear case-control split (143 AVF cases, 286 non-AVF controls).
• Analysis includes specific statistical metrics, such as odds ratios (OR=1.045 for age, OR=2.85 for BMD) and AUC values for predictive models.
• Clinical variables are precisely defined, including BMD T-scores and BMI measurements with reported standard deviations.

Limitations

• Small sample size of 429 patients from a single hospital limits generalizability.
• Temporal coverage from 2019 to 2024 may not reflect long-term outcomes or latest surgical techniques.
• Predictive performance of individual features was limited, with age and BMD each having an AUC below 0.63.

Provenance

Source

Retrospective patient records from the Fourth Affiliated Hospital of Xinjiang Medical University.

Collection Method

Clinical data collection and statistical analysis (univariate and binary logistic regression) performed for a research study.

Time Range

January 2019 to December 2024.

Freshness

Data covers patient records up to December 2024, with study publication in 2026.

Geography

Patients treated at a single hospital in China.