Risk Factors for Pulmonary Complications in Systemic Lupus Erythematosus: A Meta-Analysis

A 2025 meta-analysis by Ze Yang synthesizes evidence from 16 studies comprising 6,978 participants on risk factors for pulmonary complications in systemic lupus erythematosus. The study systematically stratifies factors for infectious pneumonia and interstitial lung disease using an evidence stratification framework. The results were published on figshare in March 2026.

Use Cases

• Compare risk factor architectures for infectious pneumonia and interstitial lung disease based on the stratified findings.
• Identify robust independent risk factors like advanced age and immunosuppressant use for infectious pneumonia.
• Investigate preliminary independent risk factors like Raynaud's phenomenon and anti-Sm antibody positivity for interstitial lung disease.
• Study the dual role of serum IgG levels as a protective factor for one complication and a risk factor for the other.

Strengths

• Evidence is synthesized from 16 studies with a total of 6,978 participants.
• Analytical approach uses an advanced evidence stratification framework integrating univariate and multivariate-adjusted results.
• Dataset is openly licensed under CC-BY-4.0.
• Systematic review protocol is registered with PROSPERO (CRD420251020965).

Limitations

• Dataset is a 12.9 KB DOCX file, suggesting it contains summary text or tables rather than raw, analyzable data.
• Column-level documentation and sample data are unavailable, making direct computational analysis impossible.
• The data scope is limited to the synthesis presented in the meta-analysis.

Provenance

Source

figshare, author Ze Yang.

Collection Method

Comprehensive literature search in seven electronic databases from inception to September 2025, followed by meta-analysis.

Time Range

Literature search covered studies from database inception to September 2025.

Freshness

Last updated 2026-03-18 07:34:16.