Mouse Behavioral and Molecular Data on S-ketamine Effects for Chemotherapy Pain

A preclinical study dataset from figshare, authored by Jing Cao and last updated in April 2026. It contains results from a mouse model investigating how S-ketamine mitigates paclitaxel-induced neuropathic pain and anxiety-like behaviors. The data likely includes behavioral scores, electrophysiological recordings, and protein expression levels from the prelimbic cortex.

Use Cases

• Analyzing correlations between mechanical withdrawal thresholds and molecular markers like mGluR5 expression.
• Modeling anxiety-like behavior outcomes based on open field test and elevated plus maze metrics.
• Investigating relationships between pyramidal neuron firing rates and theta-gamma phase-amplitude coupling data.
• Studying the association between BDNF/TrkB signaling pathway upregulation and behavioral improvements.

Strengths

• Dataset is openly licensed under CC-BY-4.0, permitting broad reuse.
• Description provides specific behavioral, molecular, and electrophysiological outcome measures from the study.
• The research context is detailed, mentioning a paclitaxel-induced peripheral neuropathy model in mice.

Limitations

• The dataset is very small at 19.6 KB, indicating limited scope.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for statistical modeling.

Provenance

Source

figshare

Collection Method

Data generated from a preclinical mouse study involving behavioral tests (electronic von Frey, elevated plus maze, open field), electrophysiological recordings, immunofluorescence staining, and Western blotting.

Freshness

Last updated 2026-04-23 05:36:34; freshness should be verified