Systematic Review of S100 Proteins in IgA Vasculitis and Other Vasculitides

A 2025 systematic review synthesizes evidence from 54 human studies on S100 proteins in vasculitides. The review, authored by Zofia Podraza, focuses on the mechanistic and clinical roles of S100A8/9, S100A12, S100A4, and S100A10, evaluating their potential as biomarkers for disease activity and prognosis.

Use Cases

• Analyze the association between S100A8/9 protein levels and neutrophil-driven inflammation in systemic vasculitides.
• Evaluate the evidence for S100A12 as a biomarker for disease activity in IgA vasculitis (IgAV).
• Compare the fragmentary findings on S100A4 and S100A10 across different forms of vasculitis.
• Synthesize narrative data from studies included in the PRISMA-compliant review to identify gaps in IgAV-specific research.

Strengths

• Synthesizes findings from 54 original human studies, providing a broad evidence base.
• Focuses on four specific S100 proteins (S100A8/9, S100A12, S100A4, S100A10) with defined biological roles.
• Follows a PRISMA-compliant systematic review methodology for transparent evidence synthesis.
• Includes an independent risk-of-bias assessment for the included studies.

Limitations

• The underlying data is narrative synthesis from studies; no primary tabular data with rows and columns is provided.
• Findings for S100A4 and S100A10 are described as fragmentary and lack sufficient IgAV-specific data.
• The dataset is a 273 KB document, limiting direct computational analysis without manual extraction.

Provenance

Source

Systematic search in PubMed, Embase, Scopus, and Web of Science.

Collection Method

PRISMA-compliant systematic review of original human studies.

Time Range

Literature search up to November 18, 2025.

Freshness

Literature search conducted up to November 18, 2025; document last updated March 25, 2026.