Salivary Exosomal TB DNA Diagnostic Performance Data from a Clinical Study

130 patients with suspected pulmonary tuberculosis were enrolled to evaluate a novel non-sputum diagnostic method. The ExoNA-based saliva assay reduced turnaround time from 16 hours to 3 hours and achieved a limit of detection of 10 CFU/mL. This dataset, authored by Jun Ma and last updated in June 2026, contains the results of this molecular diagnosis study.

Use Cases

• Benchmarking diagnostic model performance based on reported sensitivity and specificity metrics.
• Analyzing the efficacy of exosomal nucleic acid detection for paucibacillary tuberculosis cases.
• Studying the correlation between smear microscopy results and molecular diagnostic outcomes.
• Evaluating the potential of saliva as a non-invasive sample type for infectious disease diagnostics.

Strengths

• Includes performance metrics (sensitivity, specificity) against multiple reference standards for 130 patients.
• Reports a clinically relevant limit of detection of 10 CFU/mL and a reduced 3-hour turnaround time.
• Provides subgroup analysis for 105 patients with negative smear microscopy results.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small (125.2 KB), indicating limited scope.

Provenance

Source

figshare

Collection Method

Data likely originates from a pilot clinical study enrolling adults with suspected pulmonary tuberculosis.

Time Range

The study period is not specified in the provided metadata.

Freshness

Last updated 2026-06-01 04:19:08; freshness should be verified.

Geography

The geographic coverage of the patient cohort is not specified.