Sanyin Decoction Study: Psoriasis Mouse Model Data on Gut-Spleen-Skin Axis

A 4.7 MB Excel file from figshare contains data from a study on Sanyin decoction's effects on psoriasis. The dataset, authored by Huangchao Jia and last updated in April 2026, includes results from a mouse model assessing skin pathology, gut microbiota changes via 16S rRNA sequencing, and transcriptomic analysis of spleen and skin. Findings suggest the treatment reshapes gut bacteria and modulates immune pathways along a gut-spleen-skin axis.

Use Cases

• Analyze correlations between gut microbiota composition and skin lesion scores based on 16S rRNA sequencing and PASI score data.
• Model immune pathway activation, such as IL-17 suppression, based on transcriptomic sequencing results from skin and spleen tissues.
• Investigate the relationship between short-chain fatty acid levels and regulatory T cell abundance based on SCFA analysis and flow cytometry data mentioned in the description.

Strengths

• Data is openly licensed under CC-BY-4.0.
• The study design includes multiple data modalities: histopathology, sequencing, and biochemical analysis.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small at 4.7 MB, indicating limited scale.

Provenance

Source

figshare, author Huangchao Jia.

Collection Method

Data generated from a laboratory study using an imiquimod-induced psoriasis-like mouse model, with treatments, sample collection, and sequencing.

Time Range

Study period not specified; dataset last updated in 2026.

Freshness

Last updated 2026-04-16 19:01:09; freshness should be verified.

Geography

Not specified.