Table 1_Serial passaging in vitro generates a Vero cell-adapted coxsackievirus A6 strain w

Sijin Xia uploaded a research dataset on 2026-04-28 detailing the in vitro adaptation of Coxsackievirus A6 (CVA6) in Vero cells. The dataset likely contains phenotypic and transcriptomic comparisons between two recombinant virus strains, rV10 and rV45, generated from passage 10 and passage 45. The 2.0 MB file is a DOCX document describing viral growth, cytopathic effects, receptor interaction, pathogenicity, and host transcriptomic responses.

Use Cases

• Studying viral adaptation mechanisms based on the comparison of phenotypic characteristics between rV10 and rV45 strains.
• Investigating host-pathogen interactions based on the described transcriptome profiling of signaling pathways like MAPK, TNF, IL-17, and apoptosis.
• Identifying genetic determinants of attenuation based on the sequence analysis revealing amino acid substitutions in VP1 and 3A proteins.
• Evaluating vaccine candidate immunogenicity based on the described comparative immunogenicity and pathogenicity in mice.

Strengths

• Dataset is associated with a detailed research methodology including systematic comparison of viral strains.
• The underlying study provides specific findings, such as ten amino acid substitutions in VP1 and one in 3A between the compared strains.
• Data is shared under a permissive CC-BY-4.0 license.

Limitations

• The dataset is a 2.0 MB DOCX file; the underlying structured data (e.g., sequence alignments, transcriptomic counts) is not directly accessible in a standard data format.
• Row count and column-level documentation are unknown, which may limit suitability assessment.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

Sijin Xia via figshare

Collection Method

Data generated through serial passaging of CVA6 in Vero cells and comparative analysis of recombinant viruses.

Freshness

Last updated 2026-04-28 05:27:30; freshness should be verified.