Serotonin Modulation of Cortical Theta Bursts in NREM Sleep

Gergely F. Turi's dataset contains experimental results on serotonin's role in modulating cortical theta bursts during non-rapid eye movement sleep. It includes measurements from simultaneous EEG/EMG recordings, fiber photometry of serotonin activity, and optogenetic and pharmacological manipulations. The data is stored in a 187.5 KB XLSX file.

Use Cases

• Analyze the inverse correlation between extracellular serotonin concentration and cortical theta burst occurrence.
• Model the effect of optogenetic activation of dorsal raphe serotonin neurons on theta burst rate and theta power.
• Examine changes in dentate gyrus granule cell calcium activity relative to theta burst events under pharmacological inhibition.

Strengths

• Data is derived from multi-modal recordings including EEG/EMG and fiber photometry, providing a direct link between neural activity and neuromodulation.
• The dataset captures the effects of specific experimental manipulations: optogenetic activation and pharmacological inhibition of the serotonin system.
• Published under a CC BY 4.0 license, allowing for broad academic reuse and sharing.

Limitations

• The dataset is small in scale at 187.5 KB, indicating limited sample size or number of experimental observations.
• The specific column structure and row count are unknown, complicating direct assessment of data granularity and completeness.
• Data is focused on a specific neurobiological mechanism, limiting generalizability to other brain states or neuromodulatory systems.

Provenance

Source

Gergely F. Turi via figshare.

Collection Method

Experimental data from simultaneous EEG/EMG recordings, fiber photometry, optogenetics, and pharmacology in a neuroscience study.

Freshness

Last updated on 2026-03-25.