Serum Metabolomic Profiles from Avian Reovirus Infection Study in Broiler Chickens

150 serum samples from broiler chickens were analyzed using LC-MS/MS to identify early biomarkers of avian reovirus infection. The study, authored by Asha Ranaraja and updated in 2026, detected 587 metabolites and found consistent depletion of specific lipids like LysoPC a C14:0. Pathway analysis revealed significant alterations in amino acid and one-carbon metabolism.

Use Cases

• Training classifiers for early avian reovirus detection based on lipid biomarker levels.
• Analyzing metabolic pathway disruptions in viral infection based on arginine-proline and branched-chain amino acid metabolism.
• Validating non-invasive diagnostic tools for poultry health based on serum metabolite profiles.

Strengths

• Includes 150 serum samples collected at three specific time points post-infection (24, 48, 72 hours).
• Profiles 587 metabolites with differential expression analysis for 371, 96, and 402 metabolites at each respective time point.
• Identifies specific biomarkers with high diagnostic performance, such as LysoPC a C14:0 showing near-perfect specificity (AUC ≈ 1.00).

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

figshare, author Asha Ranaraja.

Collection Method

Serum samples from ARV-challenged broilers analyzed via liquid chromatography–tandem mass spectrometry (LC–MS/MS).

Time Range

Samples collected at 24, 48, and 72 hours post-infection.

Freshness

Last updated 2026-05 08 05:51:21.

Geography

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