Serum Metabolite Levels Predicting Outcome After Brain Hemorrhage

80 patients with aneurysmal subarachnoid hemorrhage had serum concentrations of short-chain fatty acids and tryptophan-derived metabolites measured at two timepoints. The data was collected by Blanka Nagybanyai-Nagy in a prospective observational study at a tertiary neurocritical care center. The dataset was last updated in April 2026.

Use Cases

• Predict 3-month functional outcome (modified Rankin Scale) using Day 1 propionic acid and Day 9 indole-3-propionic acid levels.
• Identify risk of delayed cerebral ischemia from Day 9 tryptophan, indole-3-propionic acid, and propionic acid concentrations.
• Analyze temporal dynamics of gut-derived metabolites like short-chain fatty acids between Day 1 and Day 9 post-hemorrhage.
• Build classification models using metabolite levels (e.g., propionic acid, isobutyric acid, tryptophan) to discriminate patient outcomes.

Strengths

• Data includes 80 consecutive patients from a tertiary care center, providing a defined clinical cohort.
• Metabolite quantification was performed using LC–MS at two specific timepoints (Day 1 and Day 9) for longitudinal analysis.
• Analysis adjusted for established clinical confounders using multivariable logistic regression.

Limitations

• The dataset is small, with only 80 patient records, limiting statistical power for complex modeling.
• Geographic coverage is limited to a single neurocritical care center, which may reduce generalizability.
• The primary data is embedded in a DOCX file (15.0 KB), requiring extraction for computational analysis.

Provenance

Source

Prospective observational study by Blanka Nagybanyai-Nagy, shared via figshare.

Collection Method

Serum samples from enrolled patients were analyzed using liquid chromatography–mass spectrometry (LC–MS).

Time Range

Measurements taken on Day 1 and Day 9 after aneurysmal subarachnoid hemorrhage.

Freshness

Data reflects a study last updated in 2026.

Geography

Data collected at a tertiary neurocritical care center; specific location is unknown.