Table 1_Serum neurofilament light chain and multiple sclerosis prognosis: a systematic rev

13 studies comprising 12,513 patients were synthesized in this meta-analysis. Elevated serum neurofilament light chain (sNfL) was significantly associated with increased risks of clinical relapse and new gadolinium-enhancing lesions. The document, authored by Yejun Chen and last updated in April 2026, presents a systematic review and pooled risk ratios for multiple sclerosis progression outcomes.

Use Cases

• Evaluating the prognostic value of serum neurofilament light chain (sNfL) for clinical relapse risk in multiple sclerosis based on the meta-analysis results.
• Assessing the association between baseline sNfL levels and radiological disease activity (new T2 or gadolinium-enhancing lesions) for patient monitoring.
• Informing clinical trial design by using sNfL as a stratification biomarker based on its association with confirmed disease worsening.
• Synthesizing evidence on biomarker utility for neuroaxonal injury in multiple sclerosis to support clinical decision-making.

Strengths

• Analysis is based on a systematic review of 13 studies with a total of 12,513 patients.
• Reports specific pooled risk ratios (e.g., RR 1.42 for new clinical relapse) with confidence intervals and heterogeneity metrics (I²).
• Includes sensitivity analyses and publication bias assessment, suggesting methodological rigor.
• Clear temporal scope for the literature search (January 2015 to January 2026).

Limitations

• The dataset is a 20.9 KB DOCX document; the underlying tabular meta-analysis data is not provided as a separate, machine-readable file.
• Column-level documentation for any potential supplementary data is absent; field semantics must be inferred from the document text.
• Row count for any underlying data tables is unknown, which may limit suitability assessment for direct computational analysis.

Provenance

Source

figshare

Collection Method

Systematic review and meta-analysis of studies from PubMed, Embase, Ovid, and Cochrane databases.

Time Range

Literature search covered January 2015 to January 2026.

Freshness

Last updated 2026-04-28 05:28:07

Geography

null