Serum Otolin-1 and Otoconin-90 Levels in Vestibular Migraine and Healthy Controls

A preliminary case-control study from 2026 compares serum levels of two otoconia-derived proteins between 40 patients with vestibular migraine and 143 age- and sex-matched healthy controls. The data, published by Ange Li on figshare, includes quantified protein levels via ELISA and clinical feature correlations. Results indicate no significant elevation of Otolin-1 or OC90 in vestibular migraine, suggesting a central rather than structural pathophysiology.

Use Cases

• Training binary classification models to differentiate vestibular migraine from other vertigo causes based on normal biomarker levels.
• Analyzing temporal patterns of biomarker concentration post-attack based on the phase-dependent decrease described.
• Conducting case-control statistical analysis on protein level distributions between patient and control groups.
• Exploring correlations between clinical features and serum protein levels as mentioned in the study results.

Strengths

• Includes specific median and IQR values for Otolin-1 and OC90 levels in both patient and control groups.
• Study design details are provided, including 40 patients and 143 matched controls and the use of enzyme-linked immunosorbent assays.
• Contains exploratory analysis on phase-dependent protein level changes post-attack with reported correlation coefficients.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small at 18.8 KB, indicating limited scope.

Provenance

Source

figshare, author Ange Li.

Collection Method

Case-control study with serum samples collected during the interictal period and quantified via ELISA.

Time Range

The study period is not specified, but the dataset was last updated in 2026.

Freshness

Last updated 2026-03-18 07:43:50; freshness should be verified.

Geography

Spatial coverage is not specified.