Table 1_Serum proteomic profiling of sepsis patients reveals a protein-based diagnostic mo

Serum proteomic and metabolomic profiles from sepsis patients, including culture-negative controls and those infected with carbapenem-susceptible or carbapenem-resistant Klebsiella pneumoniae. The dataset was created by Juan He and last updated in May 2026. It includes 85 differentially expressed proteins and 128 differential metabolites identified in the study.

Use Cases

• Developing diagnostic models for carbapenem-resistant Klebsiella pneumoniae (CRKP) sepsis based on the identified four-protein biomarker panel (IGHV1-8, ITGA2, PKP1, IGFBP6).
• Analyzing host systemic molecular responses to infection by examining differentially expressed proteins and metabolites.
• Conducting integrated pathway analysis to study dysregulation in cysteine/methionine metabolism and folate-mediated one-carbon pool pathways.
• Validating candidate biomarker proteins using targeted proteomic methods like parallel reaction monitoring (PRM).

Strengths

• Includes multi-omics data with both proteomic and metabolomic profiling.
• Features an independently validated four-protein biomarker panel with a reported test AUC of 0.920.
• Data is shared under a permissive CC-BY-4.0 license.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is relatively small at 2.4 MB.

Provenance

Source

figshare

Collection Method

Serum samples from sepsis patients underwent in-depth proteomic and metabolomic profiling, with machine learning applied to construct diagnostic models.

Freshness

Last updated 2026-05-20 05:44:19; freshness should be verified.