Serum sST2 and MR-ProADM Biomarkers in Pediatric Acute Rheumatic Fever

38 pediatric patients diagnosed with acute rheumatic fever and 38 matched healthy controls form this case–control study. Serum levels of soluble suppression of tumorigenicity-2 (sST2) and mid-regional pro-adrenomedullin (MR-ProADM) were measured and analyzed against echocardiography-assessed cardiac involvement. The dataset, authored by Ecem Ipek Altınok and last updated in May 2026, is shared under a CC-BY-4.0 license.

Use Cases

• Evaluate the diagnostic performance of sST2 and MR-ProADM for acute rheumatic fever based on the reported AUC values.
• Assess the association between biomarker levels and moderate-to-severe cardiac involvement based on the multivariate logistic regression results.
• Explore biomarker utility for clinical risk stratification in pediatric cardiology, as suggested in the study's conclusion.

Strengths

• Includes a matched case–control design with 38 patients and 38 healthy controls.
• Provides specific statistical performance metrics, including AUC values of 0.81 for sST2 and 0.67 for MR-ProADM.
• Results include multivariate analysis showing sST2 independently associated with cardiac involvement (OR: 1.02).

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small at 11.1 KB, indicating limited scope.

Provenance

Source

Ecem Ipek Altınok via figshare.

Collection Method

Case–control study measuring serum biomarkers via enzyme-linked immunosorbent assay and assessing cardiac involvement via echocardiography.

Freshness

Last updated 2026-05-29 06:07:40; freshness should be verified.