Serum Steroid Hormone Profiles in Reproductive-Age Women with Systemic Lupus Erythematosus

Xiaotong Chen published a cross-sectional study comparing serum steroid hormone profiles between 39 newly diagnosed, treatment-naïve female SLE patients and 37 matched healthy controls. Hormone levels were quantified using LC-MS/MS and correlated with clinical parameters and disease activity (SLEDAI-2000). The dataset was last updated on 2026-04-22.

Use Cases

• Identify hormonal biomarkers for SLE disease activity based on correlations with SLEDAI scores and proteinuria.
• Investigate associations between specific hormone deficiencies (e.g., glucocorticoids, androgens) and inflammatory markers like IL-6 and complement levels.
• Compare hormone profiles (e.g., progesterone, estradiol) across menstrual phases in SLE patients versus healthy controls.
• Explore the relationship between elevated melatonin levels and clinical manifestations in SLE.

Strengths

• Data is from a controlled, matched study of 39 SLE patients and 37 healthy controls.
• Hormone quantification uses a precise method (liquid chromatography-tandem mass spectrometry).
• Clinical parameters include disease activity scores (SLEDAI-2000) and specific inflammatory markers.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small (16.3 KB), indicating limited scope and sample size.

Provenance

Source

Xiaotong Chen via figshare

Collection Method

Cross-sectional study with fasting blood samples collected from enrolled participants.

Freshness

Last updated 2026-04-22 05:49:32; freshness should be verified.