Serum Uric Acid and Lupus Nephritis Risk in SLE Patients: A 3-Year Longitudinal Analysis

A clinical study by Xiaolu Huang, last updated in May 2026, analyzes serum uric acid levels in systemic lupus erythematosus patients with preserved renal function. The dataset includes baseline data for 97 patients (58 with lupus nephritis, 39 without) and a 3-year follow-up for incident disease. It contains statistical results from multivariable logistic and Cox regression models evaluating the association between serum uric acid and lupus nephritis risk.

Use Cases

• Train a risk stratification model based on serum uric acid levels and clinical covariates mentioned in the study.
• Analyze longitudinal associations between a biomarker and disease progression over a 3-year follow-up period.
• Benchmark clinical prediction models using the reported Area Under the Curve (AUC) discrimination metrics.
• Study treatment effects by incorporating variables for glucocorticoid dose, mycophenolate mofetil, and cyclophosphamide use.

Strengths

• Contains longitudinal data with a 3-year follow-up period for incident disease analysis.
• Reports specific statistical results, including adjusted odds ratios (OR 4.20, 95% CI 2.00–8.83) and hazard ratios (HR 1.83, 95% CI 1.09–3.07).
• Includes a clearly defined cohort of 97 SLE patients with preserved renal function.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for machine learning tasks.
• The data is contained in a DOCX file (2.0 MB), which may require parsing to extract structured tabular data.

Provenance

Source

Xiaolu Huang via figshare.

Collection Method

Clinical study enrolling patients with systemic lupus erythematosus and preserved renal function.

Time Range

Study includes a 3-year longitudinal follow-up period.

Freshness

Last updated 2026-05-07 04:47:16; freshness should be verified.