Sex Hormones and Gastrointestinal Disorders in Menopausal Women Review

A 2026 narrative review by Zijun LI synthesizes research on the molecular mechanisms linking sex hormones to functional gastrointestinal disorders in menopausal women. The document explores the role of hormone replacement therapy and gut microbiota in the gut-brain axis. It is a 22.2 KB DOCX file released under a CC BY 4.0 license.

Use Cases

• Analyze the proposed molecular mechanisms linking sex hormones to GI function for hypothesis generation in endocrinology research.
• Review the discussion on hormone replacement therapy (HRT) impact on gastrointestinal (GI) functionality for clinical literature synthesis.
• Extract information on the interplay between climacteric syndrome, depression/anxiety, and sleep disorders with FGIDs/DGBI for systematic review preparation.
• Study the outlined relationship between gut microbiota alterations and the gut–brain axis in the context of menopausal FGIDs/DGBI.

Strengths

• Focuses on a specific, clinically relevant population: menopausal women with functional gastrointestinal disorders.
• Explicitly covers multiple interconnected topics: sex hormones, hormone replacement therapy, gut microbiota, and the gut-brain axis.
• Released under a permissive CC BY 4.0 license, allowing for broad sharing and adaptation.

Limitations

• The dataset is a 22.2 KB narrative review document, not structured tabular data, limiting quantitative analysis.
• Contains no original patient records, experimental data, or defined rows and columns for statistical modeling.
• As a review, it presents synthesized findings rather than primary source data, which may be subject to author interpretation.

Provenance

Source

Author Zijun LI, published on figshare.

Collection Method

Narrative literature review.

Time Range

Review published in 2026; covers literature up to that point.

Freshness

Last updated March 2026.