Sex-Related Peripheral Immune Profile in Ulcerative Colitis: Links to Fatigue

A 2026 study by Thyra Albrecht presents flow cytometry and cytokine data from 89 individuals, including patients with active ulcerative colitis, patients in remission, and healthy controls. The dataset includes measurements of peripheral immune cells and plasma cytokines, correlated with fatigue scores from the Inflammatory Bowel Disease Fatigue questionnaire. The analysis explores sex-stratified links between immune dysregulation and fatigue severity.

Use Cases

• Investigating sex-specific immune correlates of fatigue based on flow cytometry data for neutrophils, monocytes, and T cell subsets.
• Analyzing relationships between disease activity (active vs. remission) and plasma cytokine levels (TNF, BDNF, IL-6, IL-18, sTREM-2).
• Building predictive models for fatigue severity in ulcerative colitis patients using peripheral immune biomarkers.
• Studying protective immune modulation during remission based on dendritic cell (plasmacytoid, CD141+) and Th9/Th22 cell data.

Strengths

• Includes data from 89 individuals across three distinct clinical groups (active UC, remission, healthy controls).
• Uses validated fatigue assessment via the Inflammatory Bowel Disease Fatigue (IBD-F) questionnaire.
• Contains sex-stratified correlation analyses for fatigue and immune subsets.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small (15.5 KB), suggesting limited scope or summary-level data.

Provenance

Source

Thyra Albrecht via figshare.

Collection Method

Flow cytometry and plasma cytokine analysis conducted on blood samples from enrolled participants.

Freshness

Last updated 2026-05-14 04:27:22; freshness should be verified.