Sex-Specific COX-2/CREB/ER Signaling in Mouse Model of Rheumatoid Arthritis Lung Disease

Experimental data from a study investigating sex-specific differences in rheumatoid arthritis-associated interstitial lung disease using a curdlan-induced SKG mouse model. The dataset likely contains histological, gene expression, and protein expression measurements related to arthritis severity, pulmonary inflammation, and fibrosis. It was authored by Misong Kim and last updated on 2026-05-20.

Use Cases

• Analyze sex-dependent differences in arthritis severity and lung fibrosis based on clinical and histological evaluations.
• Investigate correlations between estrogen receptor expression and tissue-specific disease manifestations.
• Model the role of the COX-2/CREB/ER signaling axis in fibrotic lung remodeling based on gene and protein expression data.

Strengths

• Data is derived from a controlled experimental model (curdlan-induced SKG mice) designed to study sex-specific disease manifestations.
• Analysis includes multiple data types: clinical arthritis scores, histological assessments, and quantitative gene/protein expression measurements.
• Dataset is openly licensed under CC-BY-4.0, permitting reuse with attribution.

Limitations

• The dataset is small (671.6 KB), indicating limited scope and likely a focused experimental result set.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for large-scale analyses.

Provenance

Source

figshare

Collection Method

Data generated from laboratory experiments on mice, including clinical evaluation, histology, qRT-PCR, and western blotting.

Freshness

Last updated 2026-05-20 05:50:30; freshness should be verified.