Gastric Cancer and Depression Comorbidity: Shared Genes and Pathways

Bin Liu's research dataset identifies shared molecular features between gastric cancer and depression. It contains lists of 130 gastric cancer-associated and 534 depression-associated genes, with six hub genes and associated pathways identified. The dataset was last updated on 2026-05-20.

Use Cases

• Identify candidate biomarkers for gastric cancer-depression comorbidity based on overlapping gene lists
• Analyze protein-protein interaction networks based on identified hub genes like SERPINE1 and COL4A1
• Investigate immune cell infiltration patterns in gastric cancer based on single-sample Gene Set Enrichment Analysis results
• Validate predicted miRNA-mRNA targeting relationships involving miR-21-5p and other microRNAs

Strengths

• Lists 130 gastric cancer-associated and 534 depression-associated genes
• Identifies six specific hub genes (SERPINE1, COL4A1, PDGFRB, BMP1, NOTCH3, EDNRA)
• Data sourced from established databases (Gene Expression Omnibus, DisGeNET, GeneCards)
• Includes experimental validation via real-time quantitative PCR and Western blot

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• The 692.9 KB file size suggests a limited scope of data

Provenance

Source

Gene Expression Omnibus, DisGeNET, and GeneCards databases

Collection Method

Bioinformatics analysis including Gene Ontology, KEGG, and protein-protein interaction network methodologies

Freshness

Last updated 2026-05-20 08:07:28