PTPRR Expression in Pancreatic Cancer: Single-Cell and Spatial Transcriptomic Profiles

1.9 MB of tabular data from a study investigating the role of protein tyrosine phosphatase receptor R (PTPRR) in pancreatic ductal adenocarcinoma (PDAC). The dataset, last updated in May 2026 and shared under a CC-BY-4.0 license by author Runyang Li, integrates public datasets like TCGA-PAAD and GSE79668 and includes results from survival, mutation, and functional analyses. It reveals PTPRR's upregulation in metastatic PDAC and its association with poor prognosis, KRAS/TP53 mutations, and an immunosuppressive microenvironment.

Use Cases

• Identify prognostic biomarkers for pancreatic cancer based on PTPRR expression levels and patient survival data.
• Analyze gene expression patterns specific to epithelial cells within pancreatic tumors using single-cell transcriptomic data.
• Investigate correlations between gene expression, tumor mutation burden (TMB), and specific mutations like KRAS and TP53.
• Study cell-cell communication networks within the tumor microenvironment, such as interactions between epithelial cells and cancer-associated fibroblasts (iCAFs).
• Explore associations between gene expression and metastatic potential or immunosuppressive microenvironments in cancer.

Strengths

• Data integrates multiple public sources, including TCGA-PAAD and GSE79668, for cross-validation.
• Analysis includes multi-modal validation through survival analysis, mutation evaluation, and in vitro functional assays.
• The dataset is focused on a specific gene (PTPRR) and cell type (epithelial cells) within a well-defined cancer context.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for large-scale analyses.
• Description metadata is limited; actual data quality and structure require manual inspection after download.

Provenance

Source

figshare

Collection Method

Integrated analysis of public datasets (TCGA-PAAD, GSE79668) combined with original single-cell/spatial transcriptomic and functional assay data.

Freshness

Last updated 2026-05-13 05:57:40; freshness should be verified.