An integrative single-cell atlas of human prenatal thymocytes from 7 to 23 post-conception weeks, constructed by Yang Yang by combining five published datasets. The data delineates asymmetric dynamics of CD4+ and CD8+ T cell lineage commitment, identifying transitional populations and developmental paths.
Use Cases
- Characterize developmental dynamics of T cells based on pseudotime analysis mentioned in the description
- Model cell-cell communication networks based on interaction data with thymic stromal cells
- Identify gene expression patterns encompassing activation and differentiation programs based on regulon profiling
- Analyze asymmetric signaling activities between CD4 and CD8 lineage intermediates based on TCR and cytokine signaling enrichment
Strengths
- Integrates data from five published datasets, providing a consolidated view
- Focuses on a specific developmental window from 7 to 23 post-conception weeks
- Data is licensed under CC-BY-4.0, facilitating open reuse
Limitations
- Row count is unknown, which may limit suitability assessment
- Column-level documentation is absent; field semantics must be inferred after download
- The dataset is 10.7 KB, indicating a very limited scope, likely summary tables rather than raw expression data
Provenance
- Source
- figshare
- Collection Method
- Combined five published datasets to construct an integrative atlas.
- Time Range
- 7 to 23 post-conception weeks
- Freshness
- Last updated 2026-05-19 05:41:50; freshness should be verified