SIRL-1/IL-8 Ratio: A Novel Diagnostic Biomarker for Inflammatory Bowel Disease

Zhengzheng Wang published a dataset on 2026-04-17 containing results from a study of 90 participants investigating the Signal Inhibitory Receptor on Leukocytes-1 (SIRL-1) and Interleukin-8 (IL-8) in Inflammatory Bowel Disease. The data includes quantified protein and gene expression levels, serum cytokine concentrations, and statistical analyses supporting a novel diagnostic ratio. The dataset is 12.5 KB in size and shared under a CC-BY-4.0 license on figshare.

Use Cases

• Validate the diagnostic accuracy of the SIRL-1/IL-8 ratio based on the reported AUC values of 0.82 for IBD and 0.86 for Crohn's Disease.
• Investigate the inverse correlation between neutrophil SIRL-1 expression and serum IL-8 levels based on the reported Spearman correlation (r = -0.5789).
• Compare biomarker performance between Ulcerative Colitis and Crohn's Disease subgroups based on the described differential IL-8 elevation.
• Replicate statistical analyses such as ROC curve, Mann-Whitney U, and Kruskal-Wallis tests using the underlying study data.

Strengths

• Includes data from a controlled study of 90 participants (IBD patients and healthy volunteers).
• Reports specific statistical results, including a correlation coefficient of r = -0.5789 and AUC values of 0.82 and 0.86.
• Measures multiple biological levels: protein expression (flow cytometry), gene expression (RT-qPCR), and serum cytokine levels (microbead array).

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small at 12.5 KB, indicating limited scope.

Provenance

Source

Zhengzheng Wang via figshare

Collection Method

Peripheral venous blood was collected from participants. Neutrophil SIRL-1 protein was quantified by flow cytometry, VSTM1 and IL-8 mRNA by RT-qPCR, and serum IL-8 by flow cytometry microbead array.

Freshness

Last updated 2026-04-17 04:12:14; freshness should be verified.