SLy1-Deficiency Results in Impaired, Exhausted and Senescent NK Cells

A dataset from a mouse model study investigating the role of the SLy1 adapter protein in natural killer (NK) cell function. The data likely contains phenotypic and functional measurements comparing SLy1- and p53-deficient NK cells to wild-type controls. The dataset was authored by Lisa Rebmann and last updated on June 4, 2026.

Use Cases

• Analyze the relationship between SLy1 deficiency and NK cell viability based on the reported reduction in cell numbers.
• Investigate p53-mediated cytotoxicity impairment in NK cells based on the described functional assays.
• Study markers of cellular senescence and exhaustion in lymphocytes based on the observed phenotypic alterations.
• Correlate genetic mutations with immunodeficiency phenotypes based on the association with human SLy1-mutations.

Strengths

• Data is derived from a genetically engineered SLy1WT/KO; p53WT/KO mouse strain, providing controlled comparisons.
• The study links molecular mechanisms (ribosomal instability, p53 accumulation) to cellular phenotypes (viability, cytotoxicity).
• The dataset is licensed under CC-BY-4.0, allowing for open sharing and reuse.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The 1.4 MB file size suggests a small dataset, potentially limiting statistical power.

Provenance

Source

figshare

Collection Method

Data generated from laboratory experiments on genetically modified mouse models.

Freshness

Last updated 2026-06-04 05:40:02; freshness should be verified.