COORDINATE: Agent-Based Model of Early T Cell Priming in Lymph Nodes

An agent-based model named COORDINATE simulates early T cell priming within the spatially structured lymph node. The model integrates fibroblastic reticular cell topology, chemokine-guided migration, and competition for dendritic cell access. It was authored by Laia Vancells and last updated on June 2, 2026.

Use Cases

• Simulating the impact of stromal architecture on T cell scanning based on the described fibroblastic reticular cell topology.
• Analyzing competition for antigen access based on the described model of limited dendritic cell availability.
• Investigating the relationship between cell trafficking biases and clonal recruitment based on the described chemokine-guided migration rules.
• Testing hypotheses about whether activation failure stems from access limitation or signaling impairment based on the model's described mechanisms.

Strengths

• Model integrates three key biological mechanisms: stromal topology, chemokine guidance, and cell competition.
• The underlying research is published under the open CC-BY-4.0 license.
• The dataset is a 3.2 MB file, making it a relatively small download.

Limitations

• The dataset is a DOCX document; the underlying model data or code is not directly specified.
• Row count and column-level documentation are unknown, limiting suitability assessment.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare

Collection Method

Spatially explicit agent-based model developed for research.

Freshness

Last updated 2026-06-02 05:40:19; freshness should be verified.