Glioblastoma Tumor-Associated Macrophage Heterogeneity Review

A 14.5 KB Excel file containing a review on spatiotemporal and metabolic heterogeneity of tumor-associated macrophages in glioblastoma. The work by Jun Lu integrates single-cell and spatial multi-omics insights to propose therapeutic targeting strategies. The dataset is licensed under CC BY 4.0.

Use Cases

• Analyze the lineage competition landscape between microglia, border-associated macrophages (BAMs), and bone marrow-derived macrophages (BMDMs) described in the review
• Map context-dependent enrichment of immunosuppressive TAMs, BAMs in perivascular zones, and HMOX1+ TAMs in hypoxic regions based on spatial organization data
• Investigate metabolic interactions like glycolysis, amino acid catabolism, and lipid accumulation between TAMs and glioma cells outlined in the dataset
• Evaluate therapeutic strategies such as metabolic-epigenetic interference and phagocytosis checkpoint blockade targeting the CD47-SIRPα axis

Strengths

• Provides an integrative review framework based on the latest single-cell and spatial multi-omics data
• File size is 14.5 KB, ensuring quick download and access
• Clear CC BY 4.0 license facilitates open reuse and sharing

Limitations

• The 14.5 KB size indicates the file contains summary or review text, not primary quantitative data tables
• Unknown row and column structure limits direct analytical or machine learning applications
• Content is a synthesized review, not raw experimental or observational measurements

Provenance

Source

figshare, author Jun Lu

Collection Method

Literature review and synthesis of published single-cell and spatial multi-omics studies

Time Range

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Freshness

Last updated March 26, 2026.

Geography

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