Mouse Dentate Gyrus Gene Expression Patterns After Entorhinal Denervation

Jessica Schlaudraff's dataset contains whole-genome expression analysis from laser-microdissected mouse dentate gyrus tissue following perforant path transection. The data likely captures transcriptomic changes across five post-lesion time points (1, 3, 7, 14, and 28 days) in two distinct brain layers. It was last updated on May 19, 2026.

Use Cases

• Model temporal dynamics of neuroinflammation based on described upregulation of glial and inflammatory factors.
• Identify compensatory plasticity mechanisms based on described upregulation of postsynaptic and dendritic membrane remodeling factors.
• Analyze layer-specific transcriptional responses based on comparisons between the outer molecular layer (OML) and granule cell layer (GCL).
• Study synaptic reorganization following injury based on described changes in synaptic adhesion mediators and neurotransmission factors.

Strengths

• Data is derived from laser microdissection, enabling layer-specific (OML and GCL) analysis.
• Time-series design includes five distinct post-lesion time points (1, 3, 7, 14, and 28 days).
• The dataset provides specific fold-change examples, such as a 3-fold induction of Nrp1 in the OML.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data is specific to a mouse model of entorhinal denervation, limiting generalizability.

Provenance

Source

Jessica Schlaudraff via figshare

Collection Method

Whole-genome expression analysis on laser-microdissected tissue from mouse dentate gyrus after surgical lesion.

Time Range

Observations at 1, 3, 7, 14, and 28 days post-lesion.

Freshness

Last updated 2026-05-19 05:40:49; freshness should be verified.