Staphylococcus argenteus ST2250 Genomic Data from Diabetic Foot Sepsis

A 2026 study by Hongdong Zhao integrates clinical data, antimicrobial susceptibility testing, and whole-genome sequencing for four Staphylococcus argenteus isolates from a diabetic foot sepsis case. The data includes comparative analysis against 370 global genomes, assessing clonal relatedness, resistance, and virulence genes. The file is a 356.1 KB DOCX document.

Use Cases

• Analyzing clonal transmission between wound and blood isolates based on core-genome SNP analysis.
• Profiling antimicrobial resistance signatures based on the prevalence of specific AMR genes like blaZ, fosB, tet(L), and APH(3')-IIIa.
• Comparing virulence gene carriage across sequence types based on features like clfB, set23, ESAT-6 system components, and the cap8 operon.
• Investigating the global dominance and temporal distribution of the ST2250 clone based on analysis of 370 genomes.
• Studying host-pathogen interactions in high-risk diabetic populations based on integrated clinical and genomic data.

Strengths

• Includes paired isolates from a septic shock case, allowing validation of clonal transmission.
• Comparative analysis against 370 global genomes provides a broader epidemiological context.
• Integrates multiple data types: clinical data, antimicrobial susceptibility testing, and whole-genome sequencing.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small (356.1 KB), indicating limited scope.

Provenance

Source

Hongdong Zhao

Collection Method

Clinical data integration, antimicrobial susceptibility testing, and whole-genome sequencing.

Freshness

Last updated 2026-04-29 05:56:59; freshness should be verified.