Table 1_STAT1 and IL-7 as potential diagnostic biomarkers for distinguishing high-grade fr

71 differentially expressed immune-related genes were identified from transcriptome RNA-seq data of High-Grade and Low-Grade Serous Ovarian Carcinoma. The dataset, authored by Zhuna Wu and last updated in April 2026, includes analysis from GEO cohorts (GSE27651, GSE126132) and validation in an independent merged cohort of 68 samples (55 HGSOC, 13 LGSOC). It focuses on STAT1 and IL-7 as potential diagnostic biomarkers and their correlation with tumor-infiltrating immune cells.

Use Cases

• Train a binary classifier to distinguish HGSOC from LGSOC based on STAT1 and IL-7 expression levels.
• Analyze correlations between gene expression and immune cell fractions (e.g., M1 macrophages, neutrophils) using the CIBERSORT algorithm results.
• Validate diagnostic biomarker performance using ROC curve analysis and AUC metrics provided in the study.
• Explore functional enrichment of differentially expressed genes in cytokine-mediated signaling and JAK-STAT pathways.

Strengths

• Validation performed in an independent merged cohort of 68 samples (55 HGSOC, 13 LGSOC).
• Biomarker performance quantified with AUC values (e.g., 0.908 for STAT1 in train group).
• Analysis includes immunohistochemistry validation of protein expression differences (P < 0.05).
• Immune microenvironment analysis includes FDR-corrected statistical results (q < 0.05).

Limitations

• Row count and column-level documentation are absent; field semantics must be inferred after download.
• The dataset is very small (11.0 KB), indicating limited raw data scope, likely containing summary results or a single table.
• Clinical utility of the biomarkers requires prospective validation, as noted in the conclusion.

Provenance

Source

Transcriptome RNA-seq data from GEO database (GSE27651, GSE126132, GSE14001, GSE73168, GSE146965).

Collection Method

Differential expression analysis, LASSO regression, mSVM-RFE feature selection, and CIBERSORT algorithm for immune cell estimation.

Freshness

Last updated 2026-04-14 04:15:00