STAT3 Signaling and Neuroimmune Dysregulation in Dravet Syndrome and Pediatric Epilepsy

A clinical and transcriptomic dataset supporting a study on neuroimmune dysregulation in Dravet syndrome and pediatric drug-resistant epilepsy. The data includes transcriptomic profiling from Scn1a+/- mice and clinical validation from a pediatric cohort of 140 patients. Author Qi Zhang published the dataset on figshare in April 2026 under a CC-BY-4.0 license.

Use Cases

• Validate systemic inflammatory indices (NLR, SII, CRP) as clinical indicators for pediatric drug-resistant epilepsy.
• Analyze correlations between central p-STAT3 activation and peripheral inflammatory markers.
• Investigate the JAK-STAT signaling pathway's role in neuroimmune dysregulation in epilepsy models.
• Assess the association of CRP levels with progression to drug resistance using multivariable analysis.

Strengths

• Includes multi-level integrative analysis combining transcriptomic data and clinical validation from a 140-patient pediatric cohort.
• Mechanistic validation performed in Scn1a+/- mice via qRT-PCR, Western blotting, and immunofluorescence.
• Clinical analysis identified CRP as an independent factor associated with drug resistance (OR=2.79, p=0.025).

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is very small (19.7 KB), indicating limited scope, likely containing summary or supporting tables rather than raw experimental data.

Provenance

Source

figshare, author Qi Zhang.

Collection Method

Multi-level integrative analysis combining transcriptomic mining of the GEO database with clinical validation from a hospital pediatric cohort and mechanistic verification in mouse models.

Time Range

The study period is not specified.

Freshness

Last updated 2026-04-13 12:12:35; freshness should be verified.

Geography

The clinical cohort is from a single hospital; geographic origin is not specified.