An Excel dataset from figshare, last updated April 22, 2026, contains gene expression data from a study by Paula Vázquez. The research investigated transcriptional programs underlying metabolic, fibrotic, vascular, and immune dysregulation in uterine leiomyomas using long-term organ cultures of myometrium and MED12-mutant leiomyoma tissue.
Use Cases
- Identify differential gene expression signatures between normal myometrium and leiomyoma tissues based on the described transcriptional profiles.
- Analyze pathways related to hypoxia, stemness, and metabolic reprogramming based on the induction of HMGA1, HMGA2, and PLAG1 mentioned in the description.
- Investigate pro-fibrotic extracellular matrix remodeling based on the described upregulation of TGFB-regulated genes and KLF factors.
- Compare immune and vascular program activation between tissue types based on the enrichment of SOX family members and endothelial genes described.
Strengths
- Data is shared under a permissive CC-BY-4.0 license.
- The study design uses physiologically relevant long-term organ culture, as highlighted in the conclusion.
Limitations
- Row count is unknown, which may limit suitability assessment.
- Column-level documentation is absent; field semantics must be inferred after download.
- The dataset is small at 29.6 KB, indicating limited scope.
Provenance
- Source
- figshare, author Paula Vázquez.
- Collection Method
- Gene expression analysis from organ cultures of myometrial and leiomyoma tissues.
- Time Range
- null
- Freshness
- Last updated 2026-04-22 05:35:57; freshness should be verified.
- Geography
- null