Rat Plasma Exosome miRNA Expression Profiles Under Hemorrhagic Stress

A study by Junxin Zhou, uploaded in 2026, explores the impact of hemorrhagic stress on plasma exosome miRNA expression in rats using high-throughput sequencing. The dataset, 775.7 KB in size, contains results revealing significant alterations in miRNA profiles, including the upregulation of miRNA-193b-3p and downregulation of miRNA-485-5p. These findings provide potential biomarkers and therapeutic targets for hemorrhage recovery.

Use Cases

• Identify potential miRNA biomarkers for hemorrhagic stress based on differential expression profiles.
• Predict target genes and pathways (e.g., TNF, MAPK signaling) regulated by stress-responsive miRNAs.
• Validate findings in rat models for applications in early diagnosis and therapeutic intervention.
• Compare miRNA expression changes associated with vascular repair and impaired cell repair.

Strengths

• Data is derived from high-throughput miRNA sequencing technology.
• Specific differentially expressed miRNAs are identified (e.g., miRNA-193b-3p, miRNA 485-5p).
• Includes pathway analysis results (e.g., TNF and MAPK signaling pathways).
• Released under a permissive CC-BY-4.0 license.

Limitations

• The dataset is small in scale (775.7 KB), suggesting limited raw data or a summary document.
• Experimental model is limited to rats; broader applicability requires further validation.
• Column-level documentation is absent; field semantics must be inferred after download.

Provenance

Source

Junxin Zhou via figshare.

Collection Method

High-throughput miRNA sequencing of rat plasma exosomes under hemorrhagic stress.

Time Range

Experimental timeframe not specified.

Freshness

Last updated 2026-04-16 04:19:10.

Geography

Geographic scope not specified.