Behavioral Variation in 13 Female C57BL/6 and C57BL/10 Mouse Substrains

13 inbred mouse substrains underwent a standardized battery of behavioral assays, including open field, cocaine locomotor response, fear conditioning, prepulse inhibition, and forced swim tests. The dataset, authored by Celine L. St. Pierre and last updated in April 2026, documents significant substrain-specific differences across all measured behaviors.

Use Cases

• Compare substrain-specific activity levels based on open field test results
• Analyze genetic influences on cocaine response based on locomotor stimulation data
• Investigate fear memory differences based on contextual and cued freezing behavior from fear conditioning
• Study sensorimotor gating variation based on acoustic startle responses from prepulse inhibition tests
• Model depressive-like behavior based on swimming metrics from the forced swim test

Strengths

• Focuses on female mice, addressing a noted underrepresentation in prior work
• Compares 13 distinct inbred mouse substrains bred in-house to control environmental effects
• Includes results from five standardized behavioral assays relevant to psychiatric models

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• The dataset is small at 34.3 KB, indicating limited scope

Provenance

Source

Celine L. St. Pierre via figshare

Collection Method

In-house breeding of substrains and standardized behavioral testing

Time Range

Experimental period not specified

Freshness

Last updated 2026-04-15 05:44:08

Geography

Laboratory setting, location not specified