Survival and Immune Dynamics in Esophageal Cancer Immunochemotherapy

304 patients with locally advanced esophageal squamous cell carcinoma were analyzed in a retrospective study comparing neoadjuvant immunochemotherapy (nICT) to chemotherapy (nCT). The data includes clinical outcomes such as 3-year overall survival rates (77.68% vs. 67.49%) and immune microenvironment metrics from multiplex immunohistochemistry. The study was authored by Yi Gan and published in 2026.

Use Cases

• Compare 3-year overall survival (OS) and disease-free survival (DFS) rates between nICT and nCT patient cohorts.
• Analyze recurrence patterns, specifically distant organ metastasis rates (10.71% vs. 26.25%), across treatment groups.
• Investigate associations between treatment response and immune microenvironment features like CD8+ T-cell infiltration and M2-like macrophage presence.
• Apply inverse probability of treatment weighting (IPTW) methods to adjust for selection bias in retrospective clinical comparisons.

Strengths

• Clinical data from 304 real-world patients provides a substantive cohort for analysis.
• Includes multiplex immunohistochemistry (mIHC) results characterizing specific immune cell dynamics.
• Study employs IPTW statistical adjustment to address selection bias in the retrospective design.
• Clear primary endpoints defined: overall survival and disease-free survival with reported hazard ratios.

Limitations

• Sample size is moderate; the nCT group contains only 80 patients, limiting statistical power for some subgroup analyses.
• Data is observational and retrospective, which may contain unmeasured confounding factors despite statistical adjustment.
• The dataset is provided as a DOCX document (2.0 MB), requiring manual extraction for structured computational analysis.

Provenance

Source

figshare, authored by Yi Gan.

Collection Method

Retrospective cohort study of patients receiving neoadjuvant treatment followed by curative esophagectomy.

Time Range

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Freshness

Last updated in March 2026.

Geography

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