Mouse Ileal Proteomic Response to Echinostoma caproni Infection

Proteomic data from ileal epithelial cells of ICR mice infected with the intestinal helminth Echinostoma caproni. The dataset, 15.7 KB in size, was created by Emma Fiallos and last updated on 2026-04-21. It quantifies differential protein expression linked to metabolic and immunological changes four weeks post-infection.

Use Cases

• Identify biomarkers of host susceptibility based on differential protein expression profiles.
• Study metabolic reprogramming during infection based on changes in mitochondrial oxidative phosphorylation and fatty acid β-oxidation proteins.
• Analyze epithelial barrier integrity based on proteins involved in tight junction maintenance and vesicular trafficking.
• Investigate immune response skewing based on the expression of antimicrobial peptides and eosinophil/neutrophil effectors.

Strengths

• Dataset is openly licensed under CC-BY-4.0.
• Proteomic analysis was performed using LC-MS/MS with both DDA and SWATH methods, as described.
• The experimental design is clearly outlined, specifying male ICR mice infected with E. caproni and ileal epithelial cells isolated at 4 weeks post-infection.

Limitations

• The dataset is very small at 15.7 KB, indicating limited scope.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

figshare

Collection Method

Proteins were extracted from isolated ileal epithelial cells of infected mice for LC-MS/MS analysis. Differential expression was quantified and analyzed with bioinformatics tools.

Freshness

Last updated 2026-04-21 04:23:09; freshness should be verified.