T-Cell Lymphoma STAT3 Variants and Regulatory Gene Expression

An Excel dataset containing molecular and cellular data comparing cancer-associated STAT3 variants Y640F and N647I. The data likely includes transcriptome-wide effects and gene expression profiles related to a T regulatory 1 (Tr1) program. The dataset was authored by Aaron B. Schultz and last updated on May 5, 2026.

Use Cases

• Compare transcriptome-wide effects of STAT3 variants Y640F and N647I based on the described retrogenic system data.
• Analyze the expression of IL-10, LAG3, and CD39 genes associated with a T regulatory 1 (Tr1) program.
• Investigate the anti-inflammatory properties of STAT3 mutants that may help transformed T cells persist.
• Correlate gain-of-function phenotypes in STAT3 variants with specific cellular pathways encouraging malignancy.

Strengths

• Data file size is 13.6 MB, indicating a substantial amount of information.
• Dataset is licensed under CC-BY-4.0, allowing for broad reuse and sharing.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare

Collection Method

Likely contains experimental data from a retrogenic system comparing STAT3 variants.

Freshness

Last updated 2026-05-05 05:25:22; freshness should be verified.