Table 1_Targeted next-generation sequencing analysis of pathogens and microecology in pedi

Hongquan Pi's dataset contains targeted next-generation sequencing results from throat swabs of 2299 children with suspected lower respiratory tract infections, published on figshare in April 2026. The data includes results for 1845 community-acquired pneumonia patients, with 293 severe cases, analyzed for pathogen detection, microbial diversity, and clinical associations. The study identified Mycoplasma pneumoniae as a dominant pathogen and linked microbial diversity shifts to disease severity.

Use Cases

• Modeling risk factors for severe community-acquired pneumonia based on pathogen positivity and patient demographics.
• Analyzing upper respiratory microbial diversity patterns associated with disease severity using Shannon/Simpson indices.
• Investigating co-occurrence or competition between pathogens like Mycoplasma pneumoniae and commensals like Schaalia odontolytica.
• Comparing pathogen detection profiles from throat swabs versus bronchoalveolar lavage fluid for diagnostic method validation.

Strengths

• Includes data from 2299 pediatric patients, providing a substantial clinical cohort.
• Contains detailed analysis for 1845 CAP cases, with 293 severe and 1552 non-severe cases for comparison.
• Licensed under CC-BY-4.0, permitting open sharing and adaptation.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data is from a single-center retrospective study, which may limit generalizability.

Provenance

Source

figshare, author Hongquan Pi.

Collection Method

Retrospective analysis of throat swab samples from pediatric patients using targeted next-generation sequencing.

Time Range

Study period includes an outbreak peaking in July 2024.

Freshness

Last updated 2026-04-16 05:14:22; freshness should be verified.

Geography

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