A longitudinal transcriptomic analysis of skin lesions and draining lymph nodes in a BALB/c mouse model infected with Leishmania braziliensis, spanning from 2 hours to 77 days post-infection. The dataset, created by Jessica Lobo-Silva and shared on figshare, includes differential gene expression, pathway enrichment, and gene co-expression network data. It was last updated in May 2026.
Use Cases
- Identify host-directed therapeutic targets based on conserved non-coding RNAs and epigenetic regulators.
- Analyze stage-specific host immune responses based on temporal gene expression profiles.
- Compare inflammatory pathways between mouse models and human disease based on pathway recapitulation data.
- Investigate gene modules associated with tissue damage and skin barrier remodeling based on co-expression analysis.
Strengths
- Provides a detailed temporal framework with data points at 2, 6, and 48 hours and at 14, 35, and 77 days post-infection.
- Includes cross-species comparison identifying 16 conserved microRNAs and 12 shared epigenetic regulators.
- Mouse lesions at Day 35 recapitulated 77% of inflammatory pathways described in human cutaneous leishmaniasis.
Limitations
- Column-level documentation is absent; field semantics must be inferred after download.
- Row count is unknown, which may limit suitability assessment.
- The dataset is very small at 19.6 KB, indicating limited scope.
Provenance
- Source
- figshare
- Collection Method
- Bulk RNA sequencing performed on skin lesions and draining lymph nodes from a BALB/c mouse dermal infection model.
- Time Range
- Data collected from 2 hours to 77 days post-infection.
- Freshness
- Last updated 2026-05-12 04:20:19