Temporal Trends in Artemisinin Resistance Mutations in Tanzania, 2021–2023

2,866 Plasmodium falciparum isolates from Tanzania's Kagera region were genotyped between 2021 and 2023 to track antimalarial drug resistance. Alfred Simkin published this dataset on figshare, showing the R561H mutation's regional prevalence rose from 5.5% to 6.9% over three years, with its first appearance in new districts indicating eastward spread. The data highlights notable variation in mutation prevalence and the co-occurrence of high-level resistance markers.

Use Cases

• Modeling the spatial spread of artemisinin partial resistance based on mutation prevalence across seven districts
• Analyzing temporal trends in validated (R561H, A675V) and candidate (V568G, P441L) K13 mutations over a three-year period
• Investigating the co-occurrence and spatial colocalization of DHFR I164L and DHPS A581G high-level resistance markers
• Assessing the regional gradients and near-fixation of early DHFR and DHPS mutations associated with partner drug sensitivity

Strengths

• Contains genotype data for 2,866 Plasmodium falciparum isolates, providing a substantial sample size.
• Covers a three-year time series (2021–2023) across seven districts, enabling temporal and spatial analysis.
• Targets 121 molecular inversion probes for key resistance loci, suggesting a focused and high-resolution genotyping approach.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for large-scale modeling.
• The 97.3 KB file size indicates a tiny dataset with potentially limited scope or aggregated summary data.

Provenance

Source

Alfred Simkin via figshare.

Collection Method

Genotyping of Plasmodium falciparum isolates using 121 molecular inversion probes targeting key resistance loci.

Time Range

2021–2023

Freshness

Last updated 2026-06-02 22:02:24; freshness should be verified.

Geography

Seven districts in the Kagera region, Northwestern Tanzania.