Systematic Review on Non-IgE Cow's Milk Allergy with Multi-Omics Corroboration

39 studies of infants aged 0–3 years with physician-confirmed non-IgE-mediated cow's milk allergy were synthesized following PRISMA guidelines. Wei Kong authored this review, which integrates evidence from a systematic literature search and an analysis of public single-cell RNA sequencing datasets. The work was last updated in April 2026 and is shared under a CC-BY-4.0 license.

Use Cases

• Validate the AhR–TLR4 mechanistic pathway in allergy based on integrated multi-omics evidence.
• Assess the predictive power of the Bifidobacterium/Enterobacteriacea ratio for persistent allergy based on the reported HR and AUC.
• Investigate the effects of synbiotic interventions on symptom resolution based on the 67% outcome mentioned.
• Explore single-cell RNA sequencing signatures for intestinal epithelial cell dysfunction described in the review.

Strengths

• Evidence synthesis from 39 physician-confirmed studies provides a structured foundation.
• Integrates public single-cell RNA sequencing data for cellular-level corroboration.
• Reports specific predictive metrics, including a hazard ratio of 1.9 and an AUC of 0.82 for the B/E ratio.

Limitations

• The dataset is a 22.5 KB DOCX file, indicating a limited scope focused on review text rather than raw data.
• Column-level documentation and sample data are unavailable, requiring full download for content inspection.
• Row count and underlying data tables are unknown.

Provenance

Source

figshare, author Wei Kong.

Collection Method

Systematic review of literature and integrative analysis of public scRNA-seq datasets.

Time Range

Studies focus on infants aged 0–3 years.

Freshness

Last updated 2026-04-14 05:39:07.

Geography

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